Molecular Neurosurgery with Targeted Toxins

Bell Wiley

Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer s disease in animals is treated in detail to give a potential user the knowledge to co